SYNTHETIC, SPECTRAL, ANTIMICROBIAL AND QSAR STUDIES ON NOVEL MANNICH BASES OF GLUTARIMIDES
نویسندگان
چکیده
منابع مشابه
Synthesis and Antimicrobial Studies of Some Novel Mannich Bases Derived from Secondary Amines
The amino alkylation of aromatic substrates by the Mannich reaction is of considerable importance for the synthesis and modification of biologically active compounds. The Mannich derivatives of 2-Chloro 4nitrobenzamide with formaldehyde and various secondary amines were synthesized for study of their biological effects. The structures of the synthesized compounds were assigned on the basis of e...
متن کاملStudies on the Anthelmintic Property of Aminobenzylated Mannich Bases
Studies were conducted on the anthelmintic property of about 15(e-h, 1e-1h, 2d-2f and 3e-3h) synthesized aminobenzylated Mannich bases bearing N-methyl piperazine using Indian earthworms Pheritima Posthuma against piperazine citrate as standard reference. Three concentrations of each compound (0.1, 0.2, 0.3% w/v) were studied, which involved the determination of paralysis and death time of the ...
متن کاملSynthesis and antimicrobial studies of some Mannich bases carrying imidazole moiety.
3 Starting from 2-methyl-4-nitro-imidazole, new 5-(2-methyl- 4-nitro-1-imidazomethyl)-1,3,4-oxadiazole-2-thione () was synthesized and was subjected to Mannich reaction with appropriate amines to yield a new series of 3-substituted aminomethyl-5-(2-methyl-4-nitro-1-imidazomethyl)- 1,3,4-oxadiazole-2-thiones (4a-j). The structure of the title compounds was elucidated by elemental analysis and sp...
متن کاملDesign, Synthesis, Characterization, and Computational Studies on Benzamide Substituted Mannich Bases as Novel, Potential Antibacterial Agents
A series of benzamide substituted Mannich bases (1-7) were synthesized. The synthesized derivatives were authenticated by TLC, UV-Visible, FTIR, NMR, and mass spectroscopic techniques and further screened for in vitro antibacterial activity by test tube dilution method using amoxicillin and cefixime as standard drugs. The compounds 5, 6, and 7 were found to be the most active antibacterial agen...
متن کاملStudies Related to Antimicrobial Activity of Aminobenzylated Mannich Bases of Urea
An elegant synthesis of newer aminobenzylated mannich bases (6a to 6j) is described in the present study. These were synthesized by reacting aromatic aldehydes, cyclic secondary amines and a reagent with active hydrogen atom such as Urea in the presence of hydrochloric acid. The constituents of the newly synthesized compounds have been established on the basis of their physical and spectral dat...
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ژورنال
عنوان ژورنال: Journal of the Chilean Chemical Society
سال: 2010
ISSN: 0717-9707
DOI: 10.4067/s0717-97072010000300001